Mitochondrial DNA variable number tandem repeats (VNTRs): utility and problems in molecular ecology
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چکیده
منابع مشابه
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity.
Variable number tandem repeats (VNTRs) constitute a relatively under-examined class of genomic variants in the context of complex disease because of their sequence complexity and the challenges in assaying them. Recent large-scale genome-wide copy number variant mapping and association efforts have highlighted the need for improved methodology for association studies using these complex polymor...
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Variable-number tandem repeats (VNTRs) have been identified in populations of Pasteuria ramosa, a castrating endobacterium of Daphnia species. The allelic polymorphisms at 14 loci in laboratory and geographically diverse soil samples showed that VNTRs may serve as biomarkers for the genetic characterization of P. ramosa isolates.
متن کاملThe role of variable DNA tandem repeats in bacterial adaptation.
DNA tandem repeats (TRs), also designated as satellite DNA, are inter- or intragenic nucleotide sequences that are repeated two or more times in a head-to-tail manner. Because TR tracts are prone to strand-slippage replication and recombination events that cause the TR copy number to increase or decrease, loci containing TRs are hypermutable. An increasing number of examples illustrate that bac...
متن کاملVariable number of tandem repeat polymorphisms (VNTRs) in the ACAN gene associated with pectus excavatum.
To the Editor : Pectus excavatum is the most common chest wall deformity, affecting 1 in 400 live births in the United States (1). It occurs commonly in Caucasian males, and is characterized by a depression of the anterior chest wall and sternum resulting in compromised cardiac and respiratory function (2, 3). Genetic factors appear to play a part (4, 5). The CS1 domain of the aggrecan (ACAN) g...
متن کاملInterleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects
IL1RA intron 2 86-bp repeat and IL4 intron 3 70-bp repeat are VNTRs that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of IL1RA and IL4 VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of IL1RA and I...
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ژورنال
عنوان ژورنال: Molecular Ecology
سال: 1998
ISSN: 0962-1083,1365-294X
DOI: 10.1046/j.1365-294x.1998.00495.x